Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700000 | 0.88 | CTSB (0.34) | CTSLCTSSCTSKAAK1 | |
| SCHEMBL4702315 | 0.87 | AAK1 (0.33) | CTSLCTSSCTSKAAK1 | |
| SCHEMBL4703534 | 0.85 | GSK3B (0.33) | CTSLCTSSCTSKAAK1 | |
| SCHEMBL6209286 | 0.84 | KDM4E (0.36) | AAK1 | |
| SCHEMBL6209280 | 0.84 | KDM4E (0.36) | AAK1 | |
| SCHEMBL6208510 | 0.78 | CTSB (0.39) | CTSLCTSSCTSKAAK1DPP4 | |
| SCHEMBL4701834 | 0.78 | CTSB (0.39) | CTSLCTSSCTSKAAK1DPP4 | |
| SCHEMBL4701046 | 0.77 | AKR1C3 (0.34) | CTSLCTSSCTSKAAK1DPP4 | |
| SCHEMBL4700769 | 0.75 | CTSL (0.38) | CTSLCTSSCTSK | |
| SCHEMBL4700510 | 0.70 | CTSL (0.48) | CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |