Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 3/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | LGMN | Q99538 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703749 | 0.86 | CTSK (0.32) | CTSLCTSSCTSKCTSBAAK1 | |
| SCHEMBL4700607 | 0.82 | GPR88 (0.37) | MEN1ALDH1A1KMT2ACTSLCTSS | |
| SCHEMBL4701624 | 0.77 | CTSL (0.42) | CTSLCTSSCTSBDPP4 | |
| SCHEMBL4703740 | 0.77 | CTSL (0.33) | CTSLCTSSCTSKAAK1DPP4 | |
| SCHEMBL4700000 | 0.71 | CTSB (0.34) | ALDH1A1CTSLCTSSCTSKCTSB | |
| SCHEMBL4703612 | 0.70 | CTSS (0.34) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4702315 | 0.70 | AAK1 (0.33) | CTSLCTSSCTSKCTSBAAK1 | |
| SCHEMBL4704688 | 0.68 | CTSL (0.33) | CTSLCTSSCTSKCTSBLGMN | |
| SCHEMBL4703534 | 0.68 | GSK3B (0.33) | CTSLCTSSCTSKAAK1 | |
| SCHEMBL6209286 | 0.67 | KDM4E (0.36) | KDM4EALDH1A1CTSBAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2008-10-01 | — | — | EP | disclosed |