Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.36 |
| ▸ | CCKBR | P32239 | 4/20 | 0.36 |
| ▸ | CCKAR | P32238 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084912 | 0.89 | RIPK1 (0.43) | RIPK1BDKRB1CCKBRCCKARTRPV1 | |
| SCHEMBL4701105 | 0.86 | CCKBR (0.40) | RIPK1BDKRB1CCKBRCCKARALDH1A1 | |
| SCHEMBL4705804 | 0.85 | RIPK1 (0.37) | RIPK1BDKRB1CCKBRCCKARALDH1A1 | |
| SCHEMBL4702545 | 0.84 | RIPK1 (0.51) | RIPK1CYP2C9 | |
| SCHEMBL4790858 | 0.82 | RIPK1 (0.45) | RIPK1BDKRB1CCKBRCCKARSMN1; SMN2 | |
| SCHEMBL4703604 | 0.80 | BDKRB1 (0.39) | BDKRB1CCKBRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4703537 | 0.80 | BDKRB1 (0.44) | BDKRB1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL4704026 | 0.79 | PSEN1 (0.44) | CCKBRCCKAR | |
| SCHEMBL4702034 | 0.79 | BDKRB1 (0.42) | BDKRB1ALDH1A1SMN1; SMN2MAPTCCNA2 | |
| SCHEMBL4705613 | 0.79 | BDKRB1 (0.43) | BDKRB1ALDH1A1SMN1; SMN2MAPTCCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |