Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 11/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14084952 | 0.89 | BDKRB1 (0.42) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4701105 | 0.87 | CCKBR (0.40) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4702034 | 0.85 | BDKRB1 (0.42) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4704248 | 0.85 | PYGL (0.48) | BDKRB1CCNA2CDK2CCNA1CCKBR | |
| SCHEMBL4701720 | 0.83 | BDKRB1 (0.39) | BDKRB1CCNA2CDK2CCNA1 | |
| SCHEMBL4705613 | 0.82 | BDKRB1 (0.43) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4703537 | 0.81 | BDKRB1 (0.44) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4705710 | 0.80 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4702448 | 0.80 | BDKRB1 (0.46) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 | |
| SCHEMBL4703792 | 0.80 | RIPK1 (0.40) | BDKRB1CCNA2CDK2CCNA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |