Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699520 | 0.90 | LMNA (0.46) | KMT2AMEN1GAAHTTKDM4E | |
| SCHEMBL4703928 | 0.87 | MAPT (0.39) | KMT2AMEN1GAANPC1GFER | |
| SCHEMBL4698966 | 0.87 | KMT2A (0.46) | KMT2AMEN1EGFRGAAHTT | |
| SCHEMBL4702538 | 0.86 | EGFR (0.39) | KMT2AMEN1EGFRGAAHTT | |
| SCHEMBL4701575 | 0.86 | MAPT (0.42) | KMT2AMEN1GAAKDM4EMAPT | |
| SCHEMBL1773447 | 0.85 | MEN1 (0.52) | KMT2AMEN1EGFRGAANPC1 | |
| SCHEMBL4701552 | 0.83 | MAPT (0.38) | KMT2AMEN1NPC1HTTKDM4E | |
| SCHEMBL4704347 | 0.81 | ALDH1A1 (0.39) | KMT2AMEN1HTTKDM4EMAPT | |
| SCHEMBL4704350 | 0.80 | ALDH1A1 (0.43) | KMT2AMEN1GAANPC1HTT | |
| SCHEMBL1774479 | 0.79 | MAPT (0.61) | KMT2AMEN1HTTMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |