Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703928 | 0.91 | MAPT (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4699968 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4701552 | 0.87 | MAPT (0.38) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL1773998 | 0.83 | MAPT (0.45) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4701575 | 0.82 | MAPT (0.42) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4702538 | 0.82 | EGFR (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4704376 | 0.81 | KMT2A (0.48) | ALDH1A1MAPTSMN1; SMN2KDM4EHTT | |
| SCHEMBL4699964 | 0.79 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL4699520 | 0.79 | LMNA (0.46) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK | |
| SCHEMBL1774892 | 0.79 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2KDM4ESYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |