Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 5/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064792 | 0.89 | GPR119 (0.45) | GPR119KCNH2ACACBGPR183 | |
| SCHEMBL12064785 | 0.83 | GPR119 (0.39) | GPR119KCNH2ACACBGPR183 | |
| SCHEMBL12064977 | 0.83 | GPR119 (0.38) | GPR119KCNH2EIF2AK4 | |
| SCHEMBL470640 | 0.83 | MCHR1 (0.36) | GPR119KCNH2ACACBEIF2AK4 | |
| SCHEMBL462498 | 0.83 | RET (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL12064712 | 0.82 | GPR119 (0.40) | GPR119KCNH2EIF2AK4GPR183 | |
| SCHEMBL470526 | 0.81 | GPR119 (0.39) | GPR119KCNH2ACACBGPR183 | |
| SCHEMBL470751 | 0.81 | GPR119 (0.38) | GPR119KCNH2EIF2AK4 | |
| SCHEMBL12064704 | 0.81 | GPR119 (0.36) | GPR119ACACB | |
| SCHEMBL12064741 | 0.80 | GPR119 (0.38) | GPR119KCNH2GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |