Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 15/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705889 | 0.91 | PGR (0.67) | PGRNR3C1 | |
| SCHEMBL4705877 | 0.90 | PGR (0.58) | PGRNR3C1LMNAMAPT | |
| SCHEMBL4702754 | 0.83 | PGR (0.52) | PGRNR3C1 | |
| SCHEMBL4704793 | 0.83 | NR3C1 (0.68) | PGRNR3C1 | |
| SCHEMBL4702720 | 0.82 | NR3C1 (0.67) | PGRNR3C1 | |
| SCHEMBL4702908 | 0.82 | PGR (0.85) | PGRNR3C1 | |
| SCHEMBL4704371 | 0.81 | NR3C1 (0.68) | PGRNR3C1 | |
| SCHEMBL4702889 | 0.80 | NR3C1 (0.68) | PGRNR3C1 | |
| SCHEMBL4702496 | 0.80 | NR3C1 (0.70) | PGRNR3C1 | |
| SCHEMBL4706154 | 0.77 | PGR (0.47) | PGRNR3C1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532113-B1 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2008-08-06 | — | — | EP | claimed |