Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705941 | 0.89 | TP53 (0.50) | MAPTTP53SMN1; SMN2POLBCCR1 | |
| SCHEMBL4707709 | 0.88 | MAPT (0.48) | MAPTP2RX7TP53SMN1; SMN2POLB | |
| SCHEMBL4708123 | 0.83 | TP53 (0.49) | MAPTP2RX7TP53 | |
| SCHEMBL4708789 | 0.83 | P2RX7 (0.46) | MAPTP2RX7TP53SMN1; SMN2POLB | |
| SCHEMBL4707099 | 0.82 | MAPT (0.44) | MAPTP2RX7TP53SMN1; SMN2POLB | |
| SCHEMBL4705947 | 0.81 | MAPT (0.44) | MAPTP2RX7TP53SMN1; SMN2POLB | |
| SCHEMBL4706712 | 0.77 | TP53 (0.52) | MAPTTP53SMN1; SMN2POLBCCR1 | |
| SCHEMBL4705490 | 0.76 | P2RX7 (0.36) | MAPTP2RX7TP53SMN1; SMN2POLB | |
| SCHEMBL5797474 | 0.75 | ALDH1A1 (0.42) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL14279261 | 0.74 | P2RX7 (0.34) | MAPTP2RX7TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-A1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003091226-A1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-06 | — | — | WO | claimed |
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |