Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708287 | 0.89 | ALDH1A1 (0.37) | GRM2SMN1; SMN2MAPTCYP2C9CYP2C19 | |
| SCHEMBL14279261 | 0.88 | P2RX7 (0.34) | P2RX7GRM2CDC7LMNASMN1; SMN2 | |
| SCHEMBL4707108 | 0.84 | P2RX7 (0.36) | P2RX7SMN1; SMN2MAPTTP53 | |
| SCHEMBL4709715 | 0.84 | CDC7 (0.43) | P2RX7GRM2CDC7SMN1; SMN2NR1H2 | |
| SCHEMBL4707457 | 0.83 | CDC7 (0.42) | P2RX7GRM2CDC7LMNANR1H2 | |
| SCHEMBL4707397 | 0.83 | P2RX7 (0.36) | P2RX7GRM2LMNASMN1; SMN2MAPT | |
| SCHEMBL4706503 | 0.81 | P2RX7 (0.37) | P2RX7SMN1; SMN2MAPTTSHRALDH1A1 | |
| SCHEMBL4707141 | 0.78 | SMN1; SMN2 (0.34) | GRM2SMN1; SMN2MAPTKMT2AHTT | |
| SCHEMBL4705643 | 0.76 | MAPT (0.45) | P2RX7SMN1; SMN2MAPTPOLBTP53 | |
| SCHEMBL4706998 | 0.75 | SLC16A3 (0.32) | GRM2SMN1; SMN2MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |