Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4054675 | 0.92 | CHRNB4 (0.53) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4051310 | 0.92 | ALDH1A1 (0.51) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4051698 | 0.91 | ALDH1A1 (0.50) | DRD2HTR2ADRD3CHRNB4CHRNA3 | |
| SCHEMBL4045253 | 0.90 | ALDH1A1 (0.49) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4046290 | 0.89 | ALDH1A1 (0.48) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4048079 | 0.88 | ADRA1A (0.48) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4048748 | 0.86 | DRD2 (0.49) | DRD2HTR2ADRD3DRD4CHRNB4 | |
| SCHEMBL4046282 | 0.85 | ALDH1A1 (0.50) | DRD2HTR2ADRD3DRD4MEN1 | |
| SCHEMBL4052789 | 0.85 | DRD2 (0.50) | DRD2HTR2ADRD3DRD4MEN1 | |
| SCHEMBL4049282 | 0.84 | DRD2 (0.48) | DRD2HTR2ADRD3DRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-B1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2008-11-26 | — | — | EP | claimed |