Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | CCKBR | P32239 | 4/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.34 |
| ▸ | CCKAR | P32238 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045841 | 0.86 | HPGD (0.40) | HPGDSMN1; SMN2CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL4788997 | 0.82 | BDKRB1 (0.37) | HPGDSMN1; SMN2CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL6046033 | 0.77 | BDKRB1 (0.40) | HPGDSMN1; SMN2CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL4706289 | 0.72 | BDKRB1 (0.56) | HPGDSMN1; SMN2ALDH1A1KMT2ACCNA2 | |
| SCHEMBL4705023 | 0.71 | RIPK1 (0.49) | CYP2C9 | |
| SCHEMBL4704148 | 0.70 | BDKRB1 (0.61) | KMT2ACCNA2CDK2CCNA1MEN1 | |
| SCHEMBL4758773 | 0.69 | PYGL (0.52) | CCNA2CDK2CCNA1 | |
| SCHEMBL4706285 | 0.68 | BDKRB1 (0.41) | HPGDSMN1; SMN2CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL4705427 | 0.66 | BDKRB1 (0.58) | HPGDSMN1; SMN2ALDH1A1CYP2C9KMT2A | |
| SCHEMBL4033964 | 0.64 | SMN1; SMN2 (0.60) | HPGDSMN1; SMN2CYP2C19ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |