Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.49 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228787 | 0.81 | CYP2C19 (0.67) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9495103 | 0.80 | SMN1; SMN2 (0.71) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3458300 | 0.79 | ALDH1A1 (0.55) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4705977 | 0.78 | SMN1; SMN2 (0.52) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6081279 | 0.75 | SMN1; SMN2 (0.58) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6579498 | 0.74 | MAPK1 (0.68) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11412031 | 0.74 | SMN1; SMN2 (0.64) | MAPTSMN1; SMN2ALDH1A1KDM4CHPGD | |
| SCHEMBL7879000 | 0.73 | SMN1; SMN2 (0.47) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2800153 | 0.73 | ALDH1A1 (0.73) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11680494 | 0.73 | SMN1; SMN2 (0.62) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966185-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-09-10 | — | — | EP | disclosed |
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-08-16 | — | — | US | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | BACE1, BACE2, PSEN1 | KMT2A 2428/4885MEN1 4385/4885MAPT 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.