Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11182466 | 0.84 | CYP3A4 (0.63) | CYP2C19SMN1; SMN2CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL11191288 | 0.84 | HPGD (0.61) | CYP2C19SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL9495103 | 0.82 | SMN1; SMN2 (0.71) | CYP2C19SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL11622805 | 0.82 | F2R (0.62) | SMN1; SMN2CYP17A1CYP11B1CYP11B2CNR1 | |
| SCHEMBL8645993 | 0.82 | CYP2C19 (0.68) | CYP2C19CDK8SMN1; SMN2CNR1MEN1 | |
| SCHEMBL4706433 | 0.81 | KMT2A (0.54) | CYP2C19SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL4705977 | 0.80 | SMN1; SMN2 (0.52) | CYP2C19CDK8SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10663620 | 0.79 | CYP17A1 (0.76) | SMN1; SMN2CYP17A1CYP11B1CYP11B2CNR1 | |
| SCHEMBL11621912 | 0.78 | HDAC1 (0.60) | CYP2C19SMN1; SMN2MAPTHPGDMAPK1 | |
| SCHEMBL8365621 | 0.78 | CYP2C19 (0.59) | CYP2C19CDK8SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | WYETH (US) | 2007-08-16 | — | — | US | disclosed |
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191431-A1 | 2-Amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation | BACE1, BACE2, PSEN1 | CYP2C19 4304/4885CDK8 2660/4885SMN1; SMN2 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.