Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064841 | 0.89 | GPR119 (0.41) | GPR119GPR183KCNH2DPP4CYP3A4 | |
| SCHEMBL470907 | 0.86 | GPR119 (0.40) | GPR119GPR183KCNH2DPP4CYP3A4 | |
| SCHEMBL470553 | 0.83 | GPR119 (0.37) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470661 | 0.80 | GPR119 (0.47) | GPR119GPR183KCNH2CYP2C19 | |
| SCHEMBL470683 | 0.79 | OPRK1 (0.33) | GPR119GPR183 | |
| SCHEMBL470577 | 0.77 | DPP4 (0.41) | KCNH2DPP4 | |
| SCHEMBL470633 | 0.77 | DPP4 (0.41) | KCNH2DPP4 | |
| SCHEMBL461833 | 0.76 | MCHR1 (0.36) | GPR119GPR183KCNH2DPP4 | |
| SCHEMBL470902 | 0.76 | DPP4 (0.34) | GPR119GPR183KCNH2DPP4 | |
| SCHEMBL470656 | 0.75 | ALOX5AP (0.34) | GPR119KCNH2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |