Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470650 | 0.89 | GPR119 (0.39) | GPR119ALOX5APGPR183 | |
| SCHEMBL19457227 | 0.84 | GPR119 (0.42) | GPR119KCNH2EGFRKCNE1ALOX5AP | |
| SCHEMBL19450516 | 0.81 | GPR119 (0.40) | GPR119KCNH2EGFRKCNE1ALOX5AP | |
| SCHEMBL386891 | 0.81 | GPR119 (0.59) | GPR119KCNH2GPR183 | |
| SCHEMBL384915 | 0.81 | GPR119 (0.59) | GPR119KCNH2GPR183 | |
| SCHEMBL470521 | 0.81 | GPR119 (0.39) | GPR119GPR183 | |
| SCHEMBL19434409 | 0.80 | GPR119 (0.46) | GPR119KCNH2EGFRKCNE1ALOX5AP | |
| SCHEMBL470682 | 0.80 | GPR119 (0.46) | GPR119KCNH2EGFRKCNE1ALOX5AP | |
| SCHEMBL28718765 | 0.77 | GPR119 (0.43) | GPR119KCNH2EGFRKCNE1GPR183 | |
| SCHEMBL28715691 | 0.77 | GPR119 (0.43) | GPR119KCNH2EGFRKCNE1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |