Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.37 |
| ▸ | RORB | Q92753 | 5/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707974 | 0.94 | TACR1 (0.38) | TACR1RORBRORCGPBAR1KDM4E | |
| SCHEMBL4705298 | 0.90 | RORB (0.36) | TACR1RORBRORCKDM4EGRM2 | |
| SCHEMBL4708167 | 0.87 | RORB (0.36) | TACR1RORBRORCALDH1A1GAA | |
| SCHEMBL4708775 | 0.85 | TACR1 (0.39) | TACR1GPBAR1GRM2 | |
| SCHEMBL4708031 | 0.84 | NTRK1 (0.34) | TACR1RORBRORCALDH1A1 | |
| SCHEMBL4708221 | 0.83 | RORB (0.37) | TACR1RORBRORCKDM4EGRM2 | |
| SCHEMBL4638836 | 0.81 | RORB (0.37) | TACR1RORBRORCALDH1A1GAA | |
| SCHEMBL4705167 | 0.79 | NTRK1 (0.34) | TACR1RORBRORCALDH1A1 | |
| SCHEMBL4705884 | 0.79 | RORB (0.40) | TACR1RORBRORCGPBAR1KDM4E | |
| SCHEMBL4639414 | 0.79 | MAPK1 (0.36) | TACR1RORBRORCGPBAR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |