Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594764 | 0.80 | GRIN2B (0.38) | CYP2B6KDM1AMAOBATML3MBTL1 | |
| SCHEMBL11111197 | 0.77 | ALDH1A1 (0.41) | KCNN4 | |
| SCHEMBL3346414 | 0.77 | LMNA (0.35) | CYP2B6ATML3MBTL1CHRM3LMNA | |
| Hydrochloric Acid SCHEMBL11044496 | 0.76 | LMNA (0.38) | CYP2B6ATML3MBTL1CHRM3LMNA | |
| SCHEMBL11006008 | 0.71 | CHRM3 (0.48) | CHRM3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19613954 | 0.70 | CYP2B6 (0.51) | KCNN4CYP2B6HRH4ATML3MBTL1 | |
| SCHEMBL19613953 | 0.70 | CYP2B6 (0.51) | KCNN4CYP2B6HRH4ATML3MBTL1 | |
| Hydrochloric Acid SCHEMBL6529786 | 0.69 | BPTF (0.35) | LMNACYP2D6 | |
| SCHEMBL21965412 | 0.68 | BPTF (0.48) | HRH4KDM1AMAOBSIGMAR1L3MBTL1 | |
| SCHEMBL31214046 | 0.68 | CYP2B6 (0.59) | CYP2B6SIGMAR1CHRM3LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991550-A1 | AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Cellzome Limited (GB) | 2008-11-19 | — | — | EP | disclosed |
| EP-1860109-A1 | Azetidine amino pyrimidine compounds for the treatment of inflammatory disorders | Cellzome (UK) Ltd. (GB) | 2007-11-28 | — | — | EP | disclosed |
| WO-2007090854-A1 | AZETIDINE AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME (UK) LTD. (GB) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007090852-A1 | AMINO PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | CELLZOME LIMITED (GB) | 2007-08-16 | — | — | WO | disclosed |