SCHEMBL470730

SCHEMBL470730

CCc1cc(OC)c(Br)c(P(=O)(c2cc(C)c(OC)c(C)c2)c2cc(C)c(OC)c(C)c2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TUBB1 Q9H4B7 1/20 0.31
CA1 P00915 5/20 0.31
CA2 P00918 5/20 0.31
CA9 Q16790 3/20 0.31
CA12 O43570 2/20 0.31
ALOX15 P16050 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
S1PR2 O95136 1/20 0.31
S1PR1 P21453 1/20 0.31
S1PR3 Q99500 1/20 0.31
LPAR2 Q9HBW0 1/20 0.31
TAS1R3 Q7RTX0 1/20 0.30
TAS1R1 Q7RTX1 1/20 0.30
TAS1R2 Q8TE23 1/20 0.30
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL459987 0.82 MAOB (0.34) ALDH1A1TSHRHSD17B10LMNASMN1; SMN2
SCHEMBL10073381 0.81 PTGS2 (0.42) PTGS2L3MBTL1ALDH1A1TUBB1
SCHEMBL14337939 0.72 CYP3A4 (0.39) ALDH1A1TUBB1CA1CA2CA9
SCHEMBL14337960 0.71
SCHEMBL6413134 0.71 ALDH1A1 (0.40) ALDH1A1TAS1R3TAS1R1
SCHEMBL8429647 0.71 PTGS2 (0.64) PTGS2L3MBTL1ALDH1A1TUBB1CA1
SCHEMBL14337941 0.70 CYP3A4 (0.33) ALDH1A1CA1CA2CA9CA12
SCHEMBL14337978 0.70
SCHEMBL12309883 0.69 PTGS2 (0.76) PTGS2ALDH1A1TUBB1ALOX15TSHR
SCHEMBL14337963 0.69 LMNA (0.33) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012031358-A1 BIARYL DIPHOSPHINE LIGANDS, INTERMEDIATES OF THE SAME AND THEIR USE IN ASYMMETRIC CATALYSIS KANATA CHEMICAL TECHNOLOGIES INC. (CA) 2012-03-15 WO disclosed