Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 9/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.33 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706229 | 0.89 | IDH1 (0.44) | IDH1RORBRORCSMN1; SMN2NPC1 | |
| SCHEMBL4705371 | 0.87 | IDH1 (0.43) | IDH1RORBRORCKDRCRHR1 | |
| SCHEMBL4707863 | 0.86 | IDH1 (0.44) | IDH1RORBRORCCRHR1GPBAR1 | |
| SCHEMBL4707706 | 0.86 | IDH1 (0.42) | IDH1RORBRORCKDRCRHR1 | |
| SCHEMBL4705565 | 0.84 | RORB (0.54) | IDH1RORBRORCSMN1; SMN2NPC1 | |
| SCHEMBL4706981 | 0.84 | IDH1 (0.42) | IDH1RORBRORCSMN1; SMN2NPC1 | |
| SCHEMBL6389497 | 0.84 | IDH1 (0.42) | IDH1RORBRORCKDRCRHR1 | |
| SCHEMBL4706963 | 0.84 | IDH1 (0.40) | IDH1RORBRORCSMN1; SMN2CRHR1 | |
| SCHEMBL4708052 | 0.83 | IDH1 (0.41) | IDH1RORBRORCGPBAR1 | |
| SCHEMBL27538912 | 0.83 | RORB (0.44) | IDH1RORBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |