Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775324 | 0.91 | GRM5 (0.36) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL1776124 | 0.83 | GRM5 (0.36) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL311936 | 0.76 | PRKDC (0.45) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL2244245 | 0.75 | DCPS (0.34) | GRM5KDM4EL3MBTL1 | |
| SCHEMBL4710518 | 0.73 | POLB (0.34) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL4705810 | 0.73 | ALDH1A1 (0.36) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL4705375 | 0.72 | GRM5 (0.33) | GRM5LMNAKDM4EL3MBTL1MAPK1 | |
| SCHEMBL4704785 | 0.70 | POLB (0.33) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL1775006 | 0.70 | MAPT (0.36) | GRM5TP53MAPTNPC1RAB9A | |
| SCHEMBL1775702 | 0.65 | GRM5 (0.39) | GRM5KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831226-A4 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES CO (US) | 2008-11-05 | — | — | EP | disclosed |
| EP-1831226-A2 | CHIRAL FUSED 1,2 IMIDAZO 4,5-c RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006074003-A2 | CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-07-13 | — | — | WO | disclosed |