Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27316845 | 1.00 | POLB (0.47) | POLBGBA1MEN1KMT2AEPHX2 | |
| Hydrochloric Acid SCHEMBL7858639 | 0.98 | MEN1 (0.46) | POLBGBA1MEN1KMT2AEPHX2 | |
| SCHEMBL18589498 | 0.82 | TRPA1 (0.35) | — | |
| SCHEMBL20747192 | 0.82 | TRPA1 (0.35) | — | |
| SCHEMBL18607945 | 0.82 | TRPA1 (0.35) | — | |
| SCHEMBL7864879 | 0.82 | POLB (0.57) | POLBGBA1MEN1KMT2A | |
| SCHEMBL9112753 | 0.82 | POLB (0.57) | POLBGBA1MEN1KMT2A | |
| SCHEMBL7864876 | 0.82 | POLB (0.57) | POLBGBA1MEN1KMT2A | |
| SCHEMBL18609787 | 0.82 | TRPA1 (0.35) | — | |
| SCHEMBL18577070 | 0.82 | TRPA1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1913004-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | Achillion Pharmaceuticals, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014308-A1 | 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2007-02-01 | — | — | WO | disclosed |
| WO-2005123670-A2 | CRYSTALLINE FORM OF A SUBSTITUTED PYRROLIDINE COMPOUND | THERAVANCE, INC. (US) | 2005-12-29 | — | — | WO | disclosed |
| WO-2005087722-A9 | DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE INC (US) | 2005-11-24 | — | — | WO | disclosed |
| CN-1032136-C | Preparation method of dihydropyridine-3, 5-dicarboxylic ester derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1996-06-26 | — | — | CN | disclosed |
| CN-1037512-A | Preparation method and application of dextro photoisomer of dihydropyridine-3, 5-dicarboxylate derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1989-11-29 | — | — | CN | disclosed |
| CN-1034720-A | Application of dihydropyridine-3, 5-dihydroxy acid ester derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1989-08-16 | — | — | CN | disclosed |
| CN-85103418-A | Preparation method of dihydropyridine-3, 5-dicarboxylic ester derivative | — | 1986-10-15 | — | — | CN | disclosed |