Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PLG | P00747 | 2/20 | 0.50 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9112753 | 1.00 | POLB (0.57) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL7864879 | 1.00 | POLB (0.57) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL26210924 | 0.83 | LTA4H (0.40) | POLBPLG | |
| SCHEMBL26210919 | 0.83 | LTA4H (0.40) | POLBPLG | |
| SCHEMBL4707927 | 0.82 | POLB (0.47) | POLBGBA1MEN1KMT2A | |
| SCHEMBL27316845 | 0.82 | POLB (0.47) | POLBGBA1MEN1KMT2A | |
| SCHEMBL27666282 | 0.81 | GBA1 (0.59) | POLBPLGGBA1 | |
| Hydrochloric Acid SCHEMBL7858639 | 0.81 | MEN1 (0.46) | POLBGBA1MEN1KMT2A | |
| SCHEMBL23775740 | 0.79 | POLB (0.57) | POLBPLGGBA1MEN1KMT2A | |
| SCHEMBL23775758 | 0.79 | POLB (0.57) | POLBPLGGBA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869955-B1 | N-ACYL-2-SUBSTITUTED-4-(BENZIMIDAZOLYL- OR IMIDAZOPYRIDINYL-SUBSTITUTED RESIDUES)-PIPERIDINES AS TACHYKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |
| US-6110939-A | AS A SUBSTANCE P ANTAGONISTS TREATING TACHYKININ-MEDIATED DISEASE, ASTHMA, CENTRAL NERVOUS SYSTEM DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-29 | — | — | US | disclosed |
| EP-0532456-B1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA GEIGY AG (CH) | 1995-03-29 | — | — | EP | disclosed |
| EP-0532456-A1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |