Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | PKLR | P30613 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847833 | 0.84 | PKM (0.56) | PKMPKLRL3MBTL1HTTKDM4E | |
| SCHEMBL6616459 | 0.83 | TSHR (0.56) | PKMPKLRL3MBTL1HTTKDM4E | |
| SCHEMBL2962440 | 0.81 | ALDH1A1 (0.59) | PKMPKLRHTTKMT2AMEN1 | |
| SCHEMBL4697481 | 0.80 | POLB (0.62) | PKMPKLRL3MBTL1KDM4EKMT2A | |
| SCHEMBL12655896 | 0.80 | PKM (0.52) | PKMPKLRL3MBTL1KDM4EKMT2A | |
| SCHEMBL24712032 | 0.78 | PKM (0.50) | PKMPKLRKDM4EKMT2AMEN1 | |
| SCHEMBL12621854 | 0.76 | PKM (0.49) | PKMPKLRL3MBTL1KMT2AMEN1 | |
| SCHEMBL26983350 | 0.75 | LMNA (0.52) | L3MBTL1HTTKDM4EKMT2AMEN1 | |
| SCHEMBL8109510 | 0.75 | PKM (0.48) | PKMPKLRKMT2AMEN1GAA | |
| SCHEMBL12655901 | 0.75 | PKM (0.48) | PKMPKLRL3MBTL1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569521-B2 | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-1976843-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007084595-A2 | CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |