Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 2/20 | 0.67 |
| ▸ | PRKACA | P17612 | 2/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.67 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18013427 | 0.85 | CDK5 (0.68) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 | |
| SCHEMBL4202167 | 0.84 | HSP90AA1 (0.76) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 | |
| SCHEMBL6764764 | 0.82 | HSP90AA1 (0.62) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 | |
| SCHEMBL481304 | 0.82 | PRKACA (0.62) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 | |
| SCHEMBL5229810 | 0.82 | HSP90AA1 (0.62) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 | |
| SCHEMBL627394 | 0.82 | KARS1 (0.56) | PRKACAPLK1CAMK2DMAP4K4MEN1 | |
| SCHEMBL1466904 | 0.82 | CAMK2D (0.58) | HSP90AA1AURKAPRKACAADORA2AKMO | |
| Hydrochloric Acid SCHEMBL4630422 | 0.81 | KARS1 (0.55) | PRKACAPLK1CAMK2DMAP4K4MEN1 | |
| SCHEMBL12171957 | 0.81 | MEN1 (0.64) | PRKACAPLK1CAMK2DMAP4K4MEN1 | |
| SCHEMBL316210 | 0.80 | HSP90AA1 (1.00) | HSP90AA1AURKAPRKACAADORA2AHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| EP-1781659-B1 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1781659-B1 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1781659-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-09 | — | — | EP | disclosed |
| US-20060183747-A1 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-08-17 | — | — | US | disclosed |
| WO-2005012304-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183747-A1 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | GSK3B, GSK3A, GRK3 | HSP90AA1 3758/4885AURKA 1182/4885PRKACA 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.