Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | TACR3 | P29371 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707521 | 0.90 | TACR1 (0.37) | TACR1GPBAR1EPAS1TP53MAPT | |
| SCHEMBL4707071 | 0.88 | TACR1 (0.40) | TACR1GPBAR1EPAS1TACR3TP53 | |
| SCHEMBL4708775 | 0.87 | TACR1 (0.39) | TACR1GPBAR1TACR3TP53MAPT | |
| SCHEMBL4637790 | 0.87 | ALDH1A1 (0.43) | TACR1 | |
| SCHEMBL4709658 | 0.85 | ALDH1A1 (0.38) | TACR1GPBAR1 | |
| SCHEMBL4705752 | 0.84 | ALDH1A1 (0.33) | TACR1EPAS1TACR3MAPTSMN1; SMN2 | |
| SCHEMBL4707053 | 0.82 | GPBAR1 (0.34) | TACR1GPBAR1 | |
| SCHEMBL4638510 | 0.80 | USP2 (0.40) | TACR1GPBAR1EPAS1TP53MAPT | |
| SCHEMBL4705246 | 0.79 | TACR1 (0.36) | TACR1GPBAR1EPAS1TP53MAPT | |
| SCHEMBL4639421 | 0.79 | ALDH1A1 (0.41) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |