Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 7/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708468 | 0.94 | RORB (0.41) | RORBIDH1RORCP2RX7NTRK1 | |
| SCHEMBL4708216 | 0.92 | IDH1 (0.42) | RORBIDH1RORCP2RX7CRHR1 | |
| SCHEMBL4706699 | 0.92 | RORB (0.42) | RORBIDH1RORCP2RX7 | |
| SCHEMBL27538912 | 0.87 | RORB (0.44) | RORBIDH1RORCSCN5ASCN9A | |
| SCHEMBL4706229 | 0.87 | IDH1 (0.44) | RORBIDH1RORCCRHR1SCN5A | |
| SCHEMBL4705528 | 0.86 | RORB (0.43) | RORBIDH1RORCP2RX7SCN5A | |
| SCHEMBL4708283 | 0.86 | RORB (0.39) | RORBIDH1RORCP2RX7SCN5A | |
| SCHEMBL4706981 | 0.86 | IDH1 (0.42) | RORBIDH1RORCCRHR1SCN5A | |
| SCHEMBL4709738 | 0.85 | RORB (0.42) | RORBRORCP2RX7CRHR1RPS6KA3 | |
| SCHEMBL4708689 | 0.84 | RORB (0.40) | RORBIDH1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |
| CN-1312136-C | Triazole derivatives as tachykinin receptor antagonists | LILLY CO ELI (US) | 2007-04-25 | — | — | CN | disclosed |