Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | CA3 | P07451 | 1/20 | 0.63 |
| ▸ | CA6 | P23280 | 1/20 | 0.63 |
| ▸ | CA5A | P35218 | 1/20 | 0.63 |
| ▸ | CA7 | P43166 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.63 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712242 | 0.91 | ALDH1A1 (0.63) | CASP1KDM4EALDH1A1HPGDCA12 | |
| SCHEMBL11511324 | 0.86 | ALDH1A1 (0.72) | CASP1KDM4EALDH1A1HPGDCA12 | |
| SCHEMBL5505992 | 0.84 | CASP1 (0.53) | CASP1KDM4EALDH1A1HPGDCA12 | |
| SCHEMBL4708974 | 0.83 | GRIN1 (0.59) | CASP1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL4711427 | 0.81 | MAOB (0.56) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL2032914 | 0.79 | KDM4E (0.81) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL978456 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL7527810 | 0.78 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL29963204 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL8242930 | 0.77 | ALDH1A1 (0.53) | CASP1KDM4EALDH1A1HPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |