Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.51 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.51 |
| ▸ | F12 | P00748 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709083 | 0.90 | MEN1 (0.46) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL5507387 | 0.83 | PIM1 (0.56) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL4711427 | 0.83 | MAOB (0.56) | GPR35MAOAHPGDALDH1A1F12 | |
| SCHEMBL4708955 | 0.83 | CASP1 (0.66) | HPGDALDH1A1F12KMT2AMAPT | |
| SCHEMBL8237936 | 0.77 | MEN1 (0.39) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL3273927 | 0.77 | GRIN1 (0.74) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1367996 | 0.76 | GRIN1 (0.79) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL1367953 | 0.76 | GRIN1 (0.79) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 | |
| SCHEMBL4712242 | 0.76 | ALDH1A1 (0.63) | MAOAHPGDALDH1A1KMT2AKDM4E | |
| SCHEMBL569881 | 0.75 | GPR35 (1.00) | GRIN1GRIN2AGRIN2BGRIN2CGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | claimed |
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |