Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664215 | 0.83 | MEN1 (0.65) | GRM4KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2533805 | 0.82 | SMN1; SMN2 (0.62) | GRM4KMT2AMEN1RXFP1ALDH1A1 | |
| SCHEMBL470920 | 0.82 | GRM4 (0.60) | GRM4ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL23070716 | 0.82 | KCNK3 (0.62) | GRM4KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL29684560 | 0.82 | KCNK3 (0.55) | GRM4KMT2AMEN1KDM4EMAPT | |
| SCHEMBL168594 | 0.82 | GRM4 (0.63) | GRM4KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5164235 | 0.78 | GRM4 (0.59) | GRM4KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14700785 | 0.77 | GRM4 (0.71) | GRM4KMT2AMEN1 | |
| SCHEMBL6011016 | 0.77 | GRM4 (0.58) | GRM4KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1848072 | 0.77 | LMNA (0.62) | GRM4KMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |