Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 2/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935654 | 0.86 | ALDH1A1 (0.63) | DPP4DPP8CHKAALDH1A1HRH3 | |
| SCHEMBL20238481 | 0.86 | CHKA (0.62) | DPP4DPP8CHKAALDH1A1HRH3 | |
| SCHEMBL29668952 | 0.86 | CHKA (0.62) | DPP4DPP8CHKAALDH1A1HRH3 | |
| SCHEMBL28876943 | 0.82 | CXCR4 (0.48) | CHKACXCR4MEN1CHRM2CHRM1 | |
| SCHEMBL4712397 | 0.82 | CHKA (0.55) | DPP4DPP8CHKAALDH1A1TDP1 | |
| SCHEMBL29756449 | 0.81 | ALDH1A1 (0.69) | DPP4CXCR4ALDH1A1MEN1CHRM2 | |
| SCHEMBL2921989 | 0.81 | ALDH1A1 (0.69) | DPP4CXCR4ALDH1A1MEN1CHRM2 | |
| SCHEMBL27822767 | 0.80 | DPP4 (0.57) | DPP4DPP8CHKAALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL31097546 | 0.79 | CYP2D6 (0.67) | DPP4DPP8CHKAALDH1A1MEN1 | |
| SCHEMBL4789120 | 0.78 | DPP4 (0.57) | DPP4DPP8CHKAALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959963-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007089336-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |