Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GPR6 | P46095 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935654 | 0.86 | ALDH1A1 (0.63) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL29668952 | 0.86 | CHKA (0.62) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL20238481 | 0.86 | CHKA (0.62) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL4710474 | 0.82 | DPP4 (0.50) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL3731827 | 0.81 | ALDH1A1 (0.56) | CHKADPP4DPP8ALDH1A1KDM4E | |
| SCHEMBL4789120 | 0.81 | DPP4 (0.57) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL27822767 | 0.80 | DPP4 (0.57) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL27545359 | 0.80 | CHKA (0.47) | CHKADPP4DPP8ALDH1A1HTT | |
| SCHEMBL12380552 | 0.79 | NPC1 (0.49) | CHKAALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL6698858 | 0.79 | MAPT (0.49) | CHKADPP4DPP8ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959963-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007089336-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |