Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198046 | 0.87 | ACKR3 (0.52) | FAAHMAPTHTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL4718791 | 0.87 | CHRM3 (0.47) | CNR1ACKR3 | |
| SCHEMBL3739306 | 0.83 | CHRM3 (0.47) | FAAHHTR1AHTR1DHTR1BACKR3 | |
| SCHEMBL3738423 | 0.82 | NAMPT (0.43) | FAAH | |
| SCHEMBL3210123 | 0.82 | HTR1A (0.60) | HTR1AHTR1DHTR1B | |
| SCHEMBL4710480 | 0.81 | MEN1 (0.46) | FAAHHTR1AHTR1DHTR1BACKR3 | |
| SCHEMBL3739030 | 0.81 | CYP3A4 (0.44) | FAAHACKR3ROCK2 | |
| SCHEMBL3196669 | 0.80 | FAAH (0.47) | FAAHMAPTACKR3 | |
| SCHEMBL4721274 | 0.80 | FAAH (0.44) | FAAHMAPT | |
| SCHEMBL3733689 | 0.78 | GLS (0.48) | MAPTACKR3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959947-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007075377-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |