Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710670 | 1.00 | EPAS1 (0.47) | EPAS1HTR2CKMT2AALDH1A1GAA | |
| SCHEMBL4713064 | 0.79 | RAB9A (0.46) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4713060 | 0.79 | RAB9A (0.46) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL19657107 | 0.76 | KDM4E (0.51) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL4710531 | 0.74 | TSHR (0.44) | KMT2AALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL4710729 | 0.74 | TSHR (0.44) | KMT2AALDH1A1SMN1; SMN2KDM4EHPGD | |
| (2-Chlorophenyl)(Morpholino)Methanone SCHEMBL6938284 | 0.71 | MGLL (0.68) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL4714523 | 0.70 | MEN1 (0.47) | KMT2AALDH1A1SMN1; SMN2KDM4ECYP2C19 | |
| SCHEMBL7262198 | 0.70 | FGFR1 (0.44) | KMT2AALDH1A1SMN1; SMN2KDM4ECYP2C19 | |
| SCHEMBL4714522 | 0.70 | MEN1 (0.47) | KMT2AALDH1A1SMN1; SMN2KDM4ECYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |