Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CHAT | P28329 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714522 | 0.81 | MEN1 (0.47) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4714523 | 0.81 | MEN1 (0.47) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7262186 | 0.81 | CYP1A2 (0.43) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4713060 | 0.80 | RAB9A (0.46) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4713064 | 0.80 | RAB9A (0.46) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4711231 | 0.78 | FGFR1 (0.41) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4711228 | 0.78 | FGFR1 (0.41) | FGFR1FGFR3RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL4710055 | 0.76 | KMT2A (0.44) | FGFR1FGFR3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7267902 | 0.76 | FGFR1 (0.44) | FGFR1FGFR3RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4710053 | 0.76 | KMT2A (0.44) | FGFR1FGFR3RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1203060-C | Pyridine derivatives, compositions and uses thereof | NOVARTIS AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |
| CN-1262676-A | Pyridine derivatives | NOVARTIS AG (CH) | 2000-08-09 | — | — | CN | disclosed |