SCHEMBL4710690

SCHEMBL4710690

NC(=O)c1ccccc1Cc1ccco1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.46
HPGD P15428 5/20 0.43
MAPT P10636 4/20 0.43
POLB P06746 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
TP53 P04637 2/20 0.43
HTT P42858 1/20 0.43
AURKA O14965 1/20 0.43
RPS6KB1 P23443 1/20 0.43
AURKB Q96GD4 1/20 0.43
ADRA1D P25100 1/20 0.43
GPR52 Q9Y2T5 1/20 0.42
NPSR1 Q6W5P4 2/20 0.41
APP P05067 1/20 0.41
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 3/20 0.40
HSD17B10 Q99714 3/20 0.40
TSHR P16473 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8073992 0.85 TSHR (0.51) HPGDMAPTPOLBSMN1; SMN2TP53
SCHEMBL27471634 0.83 ALDH1A1 (0.47) HPGDMAPTPOLBSMN1; SMN2TP53
SCHEMBL27541874 0.80 ALOX5 (0.41) ALOX5HPGDMAPTPOLBSMN1; SMN2
SCHEMBL7134588 0.80 TSHR (0.54) HPGDMAPTPOLBALDH1A1KDM4E
SCHEMBL27541871 0.76 ALDH1A1 (0.55) ALOX5HPGDMAPTPOLBTP53
SCHEMBL1742362 0.74 AURKA (0.56) HPGDMAPTPOLBSMN1; SMN2TP53
SCHEMBL29817906 0.74 ALDH1A1 (0.47) ALOX5HPGDMAPTPOLBSMN1; SMN2
SCHEMBL4949819 0.73 CTSA (0.38) HPGDMAPTALDH1A1KDM4EHSD17B10
SCHEMBL11131843 0.73 HSPA5 (0.58) MAPTPOLBSMN1; SMN2HTTTSHR
SCHEMBL6912345 0.73 GAA (0.41) ALOX5HPGDMAPTNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1928879-A2 FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS Brystol-Myers Squibb Company (US) 2008-06-11 EP claimed
WO-2007038314-A2 FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-04-05 WO claimed
WO-2022195522-A1 INHIBITORS OF ANO6 AND THEIR USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-09-22 WO disclosed
WO-2022157686-A1 INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2022-07-28 WO disclosed
CN-108530444-A A kind of novel NAMPT and IDO double inhibitors and preparation method thereof and medical usage 中国药科大学 2018-09-14 CN disclosed
WO-2008039007-A1 INDOL DERIVATIVES, THE METHOD FOR PREPARING THEREOF AND COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING THE SAME AS AN ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2008-04-03 WO disclosed