Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712930 | 0.88 | HRH3 (0.43) | HRH3HRH2HRH1CYP2D6CYP2C19 | |
| SCHEMBL27535050 | 0.80 | KDM4E (0.34) | HTR1AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4711565 | 0.71 | HTR1B (0.45) | HRH3HRH1ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL30395062 | 0.70 | HTR1A (0.55) | HRH3HRH2HRH1HTR1AALDH1A1 | |
| SCHEMBL19897567 | 0.70 | HTR1A (0.55) | HRH3HRH2HRH1HTR1AALDH1A1 | |
| SCHEMBL30395194 | 0.70 | HTR1A (0.55) | HRH3HRH2HRH1HTR1AALDH1A1 | |
| SCHEMBL19897751 | 0.70 | HTR1A (0.55) | HRH3HRH2HRH1HTR1AALDH1A1 | |
| SCHEMBL19897569 | 0.70 | HTR1A (0.55) | HRH3HRH2HRH1HTR1AALDH1A1 | |
| SCHEMBL19389940 | 0.69 | LTA4H (0.67) | HRH3HRH2HRH1ALDH1A1KDM4E | |
| SCHEMBL5544810 | 0.68 | LTA4H (0.69) | HRH3HRH2HRH1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |