Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710758 | 0.88 | HRH3 (0.47) | HRH3HRH2HRH1CYP2D6CYP2C19 | |
| SCHEMBL4711565 | 0.74 | HTR1B (0.45) | HRH3HRH1CYP2D6CYP2C19 | |
| SCHEMBL5205832 | 0.70 | HTR1D (0.69) | — | |
| SCHEMBL19939549 | 0.69 | CD274 (0.56) | SIGMAR1CYP2D6CYP2C19 | |
| SCHEMBL21412446 | 0.67 | ALDH1A1 (0.56) | SIGMAR1CYP2D6CYP2C19 | |
| SCHEMBL30668205 | 0.67 | CD274 (0.54) | SIGMAR1CYP2D6CYP2C19 | |
| SCHEMBL11253842 | 0.66 | HRH1 (0.57) | HRH3HRH1SIGMAR1DRD4KCNH2 | |
| SCHEMBL1101273 | 0.66 | OPRM1 (0.52) | SIGMAR1DRD4 | |
| SCHEMBL4713849 | 0.66 | GRM5 (0.57) | — | |
| SCHEMBL98426 | 0.66 | LTA4H (0.66) | HRH3HRH2HRH1SIGMAR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |