Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277944 | 0.92 | TAS1R3 (0.64) | CA12CA1CA2CA7CA9 | |
| SCHEMBL608095 | 0.92 | TAS1R3 (0.64) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8501324 | 0.89 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL2466357 | 0.89 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL4427914 | 0.89 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL9538124 | 0.84 | CA12 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10586399 | 0.82 | CA12 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10586238 | 0.81 | CA1 (0.64) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11602838 | 0.81 | MEN1 (0.57) | MTNR1AMTNR1BTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL29112431 | 0.80 | PDPK1 (0.54) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998774-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES TO ENHANCE MEMORY FUNCTION | Actelion Pharmaceuticals Ltd. (CH) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007105177-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES TO ENHANCE MEMORY FUNCTION | ACTELION PHARMACEUTICALS LTD (CH) | 2007-09-20 | — | — | WO | disclosed |