Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MEP1B | Q16820 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13603943 | 0.79 | GAA (0.50) | GAAGLAHTTRAB9ASMN1; SMN2 | |
| SCHEMBL22698650 | 0.79 | MEP1B (0.52) | MEP1BMEN1KMT2ATDP1RAB9A | |
| SCHEMBL6631803 | 0.78 | KCNH2 (0.58) | GAAL3MBTL1MEN1KMT2AGLA | |
| SCHEMBL27650715 | 0.77 | MEN1 (0.60) | MEP1BL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL19474705 | 0.76 | MEP1B (0.74) | MEP1BMEN1KMT2ATDP1HDAC3 | |
| SCHEMBL4207497 | 0.76 | MAPT (0.59) | GAAL3MBTL1MEN1KMT2AHTT | |
| SCHEMBL1290016 | 0.75 | MEP1B (0.49) | MEP1BMEN1KMT2ATDP1RAB9A | |
| SCHEMBL9721530 | 0.75 | MEP1B (0.55) | MEP1BMEN1KMT2ATDP1HTT | |
| SCHEMBL3190680 | 0.73 | MEP1B (0.53) | MEP1BMEN1KMT2ATDP1RAB9A | |
| SCHEMBL17736335 | 0.73 | CA2 (0.60) | L3MBTL1MEN1KMT2AHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943216-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007042250-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |