Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.70 |
| ▸ | MMP9 | P14780 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.58 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.58 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.58 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711155 | 1.00 | APP (0.84) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL27570859 | 0.89 | APP (0.66) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL4710990 | 0.87 | APP (0.62) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL4710991 | 0.87 | APP (0.62) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL12280972 | 0.83 | MEN1 (1.00) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL4710987 | 0.81 | JUN (0.59) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL4710988 | 0.81 | JUN (0.59) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL8854590 | 0.80 | APP (0.74) | APPMEN1RAB9AKMT2ANPC1 | |
| SCHEMBL17732299 | 0.80 | TTR (0.85) | APPMEN1KMT2APOLBMMP9 | |
| SCHEMBL671150 | 0.80 | TTR (0.85) | APPMEN1KMT2APOLBMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |