Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711228 | 0.84 | FGFR1 (0.41) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4711231 | 0.84 | FGFR1 (0.41) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7268783 | 0.83 | MAPT (0.48) | RAB9ASMN1; SMN2MAPTNPC1KMT2A | |
| SCHEMBL4713060 | 0.80 | RAB9A (0.46) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4713064 | 0.80 | RAB9A (0.46) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4710664 | 0.79 | PTGDR2 (0.45) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4713003 | 0.79 | PTGDR2 (0.45) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4710062 | 0.79 | FGFR1 (0.40) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4710063 | 0.79 | FGFR1 (0.40) | FGFR1FGFR3RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7268766 | 0.79 | PTGDR2 (0.45) | RAB9ASMN1; SMN2MAPTNPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |