Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19469344 | 0.81 | KMT2A (0.60) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL3835002 | 0.78 | PRMT5 (0.67) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL14123126 | 0.78 | PRMT5 (0.67) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL11889212 | 0.75 | PRMT5 (0.54) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL7960404 | 0.75 | PRMT5 (0.54) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL336603 | 0.75 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL449928 | 0.75 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL9101862 | 0.75 | KMT2A (0.53) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL336605 | 0.75 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL30301224 | 0.75 | PRMT5 (1.00) | PRMT5WDR77KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |