Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889212 | 1.00 | PRMT5 (0.54) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL6808021 | 0.84 | CA2 (0.44) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL6807193 | 0.84 | CA2 (0.44) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL6807174 | 0.84 | CA2 (0.44) | PRMT5WDR77KMT2ACA2MMP2 | |
| SCHEMBL9805877 | 0.77 | KMT2A (0.62) | KMT2AGAAHTTCA2MMP2 | |
| SCHEMBL11765302 | 0.76 | KMT2A (0.66) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL4712336 | 0.75 | PRMT5 (0.60) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL9398531 | 0.73 | KMT2A (0.66) | KMT2AGAAHTTCA2MMP2 | |
| SCHEMBL6544644 | 0.73 | KMT2A (0.66) | KMT2AGAAHTTCA2MMP2 | |
| SCHEMBL4804280 | 0.72 | PRMT5 (0.67) | PRMT5WDR77KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180633-B1 | TREATMENT OF DRUG RESISTANT MALARIA COMPRISING COADMINISTERING TO A MAMMAL A RESISTANCE MODULATING (CYCLOPROPYLDIBENZOSUBER-5-YL)PIPERAIN-1-YL NAPHTHALENE DERIVATIVE AND AN ANTI-MALARIAL DRUG | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-6130219-A | Drug resistance and multidrug resistance modulators | ELI LILLY AND COMPANY (US) | 2000-10-10 | — | — | US | disclosed |
| US-6025359-A | Drug resistance and multidrug resistance modulators | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0814081-A1 | Drug resistance and multidrug resistance modulators | ELI LILLY AND COMPANY (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997048689-A1 | DRUG RESISTANCE AND MULTIDRUG RESISTANCE MODULATORS | ELI LILLY AND COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |