Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | FHIT | P49789 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | GLA | P06280 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4710861 | 0.99 | KDM4E (0.60) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL4709626 | 0.86 | KDM4E (0.64) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL4710636 | 0.84 | KDM4E (0.62) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL8246402 | 0.84 | FHIT (0.56) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL4710612 | 0.84 | FHIT (0.56) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL4710578 | 0.83 | KDM4E (0.63) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL4711828 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL10506951 | 0.80 | RXFP1 (0.62) | KDM4EALDH1A1HSD17B10HPGDPOLB | |
| SCHEMBL4711017 | 0.79 | KDM4E (0.95) | KDM4EALDH1A1FHITHSD17B10HPGD | |
| SCHEMBL10505966 | 0.78 | ADRB2 (0.57) | KDM4EALDH1A1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |