Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | AKT2 | P31751 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563442 | 0.89 | ADRA2A (0.42) | CSNK1A1TYRO3DYRK1BCASP1ADRA2A | |
| SCHEMBL30979447 | 0.70 | ADRA2A (0.46) | CSNK1A1TYRO3DYRK1BADRA2AALDH1A1 | |
| SCHEMBL4329170 | 0.68 | ADRA2A (0.50) | CSNK1A1TYRO3DYRK1BCASP1ADRA2A | |
| SCHEMBL6824177 | 0.66 | MTOR (0.54) | CSNK1A1TYRO3DYRK1BADRA2AALDH1A1 | |
| SCHEMBL28678460 | 0.66 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTKDM4EAKT1 | |
| SCHEMBL39553 | 0.65 | ALDH1A1 (0.47) | CSNK1A1TYRO3DYRK1BADRA2AALDH1A1 | |
| SCHEMBL9603839 | 0.64 | SMN1; SMN2 (0.48) | CSNK1A1TYRO3DYRK1BADRA2AALDH1A1 | |
| SCHEMBL6825869 | 0.64 | CSNK1A1 (1.00) | CSNK1A1TYRO3DYRK1BALDH1A1KDM4E | |
| SCHEMBL1663671 | 0.63 | CSNK1A1 (0.53) | CSNK1A1TYRO3DYRK1BADRA2AALDH1A1 | |
| SCHEMBL21298118 | 0.63 | ADRA2A (0.49) | CSNK1A1TYRO3DYRK1BCASP1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888060-A2 | NK-B INHIBITORS FOR THE TREATMENT OF MUSCULAR DYSTROPHY | A. T. Still University of Health Sciences (US) | 2008-02-20 | — | — | EP | claimed |
| US-20060280812-A1 | Compositions and methods for the treatment of muscular dystrophy | A.T. STILL UNIVERSITY OF HEATH SCIENCES | 2006-12-14 | — | — | US | claimed |
| WO-2006127930-A2 | NK-B INHIBITORS FOR THE TREATMENT OF MUSCULAR DYSTROPHY | A. T. STILL UNIVERSITY OF HEALTH SCIENCES (US) | 2006-11-30 | — | — | WO | claimed |