Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712913 | 0.88 | GAPDH (0.34) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4714356 | 0.86 | GAPDH (0.34) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4712640 | 0.86 | HSPA1A (0.43) | BRAFHSPA1APTPN7HCRTR1HCRTR2 | |
| SCHEMBL4712071 | 0.86 | GAPDH (0.34) | BRAFHSPA1AGAPDHHSPA8MEN1 | |
| SCHEMBL4712096 | 0.85 | MEN1 (0.36) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4713072 | 0.83 | ABCC9 (0.36) | HSPA1AHCRTR2GAPDHHSPA8PTGS2 | |
| SCHEMBL6823827 | 0.83 | GAPDH (0.34) | HSPA1AGAPDHHSPA8 | |
| SCHEMBL4712066 | 0.80 | CYP3A4 (0.35) | HSPA1APTPN7GAPDHHSPA8MEN1 | |
| SCHEMBL4713720 | 0.79 | GAPDH (0.35) | HSPA1AGAPDHHSPA8MEN1KMT2A | |
| SCHEMBL4713164 | 0.78 | GAPDH (0.32) | HSPA1AGAPDHHSPA8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | claimed |
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2004069840-A2 | PRODUCTION OF TETRAHYDROQUINOLINE BENZOFURANS | Grünenthal GmbH (DE) | 2004-08-19 | — | — | WO | disclosed |