Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713012 | 1.00 | GRM4 (0.49) | GRM4PTGS2TTRALOX5PTGS1 | |
| SCHEMBL10123059 | 0.87 | GRM4 (0.56) | GRM4PTGS2TTRALOX5PTGS1 | |
| SCHEMBL10123058 | 0.87 | TTR (0.47) | PTGS2TTRALOX5PTGS1ALDH1A1 | |
| SCHEMBL8101255 | 0.86 | APP (0.46) | PTGS2TTRALOX5PTGS1ALDH1A1 | |
| SCHEMBL8101251 | 0.86 | APP (0.46) | PTGS2TTRALOX5PTGS1ALDH1A1 | |
| SCHEMBL5789872 | 0.83 | HRH4 (0.45) | PTGS2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5789877 | 0.83 | HRH4 (0.45) | PTGS2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5791786 | 0.83 | NFE2L2 (0.53) | GRM4PTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL5791782 | 0.83 | NFE2L2 (0.53) | GRM4PTGS2PTGS1ALDH1A1KDM4E | |
| SCHEMBL5788387 | 0.81 | PTGS2 (0.54) | PTGS2TTRALOX5PTGS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |
| US-5376685-A | Arylhydrazones using as SAMDC inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |
| US-5238941-A | S-adenosylmethionine decarboxylase inhibitors | CIBA-GEIGY CORPORATION (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0335832-B1 | ARYL HYDRAZONES | CIBA-GEIGY AG (CH) | 1993-02-10 | — | — | EP | disclosed |
| US-5118709-A | Decarboxylase enzyme inhibitors; antitumor agents | CIBA-GEIGY CORPORATION (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971986-A | ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0335832-A2 | Aryl hydrazones | CIBA-GEIGY AG (CH) | 1989-10-04 | — | — | EP | disclosed |