Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801258 | 0.81 | ALDH1A1 (0.37) | ALDH1A1SOAT1EPHX2OPRM1OPRL1 | |
| SCHEMBL26649008 | 0.73 | ALDH1A1 (0.44) | ALDH1A1OPRM1NAAATEAD3 | |
| SCHEMBL22034844 | 0.73 | ALDH1A1 (0.44) | ALDH1A1OPRM1NAAATEAD3 | |
| SCHEMBL10285224 | 0.68 | TACR1 (0.49) | ALDH1A1EPHX2HRH4HRH3TEAD3 | |
| SCHEMBL317686 | 0.67 | TSHR (0.58) | ALDH1A1HRH4HRH3L3MBTL1NAAA | |
| SCHEMBL941253 | 0.66 | TSHR (0.56) | ALDH1A1HRH4HRH3L3MBTL1NAAA | |
| SCHEMBL27961981 | 0.66 | TSHR (0.56) | ALDH1A1HRH4HRH3L3MBTL1NAAA | |
| SCHEMBL29098435 | 0.66 | TSHR (0.56) | ALDH1A1HRH4HRH3L3MBTL1NAAA | |
| SCHEMBL23533368 | 0.65 | ALDH1A1 (0.42) | ALDH1A1NR5A2EPHX2OPRM1OPRL1 | |
| SCHEMBL28827345 | 0.65 | ALDH1A1 (0.42) | ALDH1A1NR5A2EPHX2OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973914-A2 | TRANSFORMING GROWTH FACTOR MODULATORS | Biogen Idec MA Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007076086-A2 | TRICYCLIC SPIRO COMPOUNDS USEFUL AS TRANSFORMING GROWTH FACTOR MODULATORS | BIOGEN IDEC MA INC (US) | 2007-07-05 | — | — | WO | disclosed |