SCHEMBL4713440

SCHEMBL4713440

CCCCOC(=O)c1cccc2nc(CCl)[nH]c12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.52
TDP1 Q9NUW8 2/20 0.52
L3MBTL1 Q9Y468 2/20 0.52
ALDH1A1 P00352 9/20 0.48
MAPK1 P28482 3/20 0.48
CYP3A4 P08684 2/20 0.48
TP53 P04637 1/20 0.48
HSD17B10 Q99714 2/20 0.47
LMNA P02545 2/20 0.47
KDM4E B2RXH2 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
POLB P06746 1/20 0.42
NPC1 O15118 1/20 0.42
NFKB1 P19838 1/20 0.42
STAT1 P42224 1/20 0.42
RAB9A P51151 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7837745 0.85 TSHR (0.55) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL4713439 0.81 TSHR (0.52) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL5970052 0.80 TSHR (0.55) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL7145208 0.79 BCHE (0.38) ALDH1A1HSD17B10KDM4ECYP1A2SMN1; SMN2
SCHEMBL9197306 0.77 RIPK1 (0.48) L3MBTL1ALDH1A1HSD17B10LMNAKDM4E
SCHEMBL7003014 0.75 PLK4 (0.45) MAPK1HSD17B10LMNAKDM4ESMN1; SMN2
SCHEMBL11789735 0.75 TSHR (0.57) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL1917771 0.74 RIPK1 (0.44) L3MBTL1ALDH1A1MAPK1HSD17B10LMNA
SCHEMBL11326382 0.73 TSHR (0.77) TSHRTDP1L3MBTL1ALDH1A1MAPK1
SCHEMBL6170666 0.71 TSHR (0.53) TSHRL3MBTL1ALDH1A1HSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465889-A4 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC (CA) 2008-05-14 EP disclosed
EP-1628533-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2006-03-01 EP disclosed
WO-2004106493-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2004-12-09 WO disclosed
EP-1465889-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY AnorMED Inc. (CA) 2004-10-13 EP disclosed
WO-2003055876-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY ANORMED INC. (CA) 2003-07-10 WO disclosed